Global Markets Direct's, 'Programmed
Cell Death Protein 1 (CD279 or Systemic Lupus Erythematosus Susceptibility 2 or PD1) - Pipeline Review, H1 2016', provides in depth analysis on Programmed
Cell Death Protein 1 (CD279 or Systemic Lupus Erythematosus Susceptibility 2 or PD1) targeted pipeline therapeutics.
In turn, these insights are leading to completely new therapeutic strategies that block these mechanisms of cancer cell survival, forcing the induction of the process of programmed
cell death, or apoptosis.
ISLAMABAD -- Results of a recent clinical study have shown that an anti-cancer drug that triggers
cell death in various tumour types, may have clinical potential for some blood cancers including mantel cell lymphoma (MCL) and acute myeloid leukaemia (AML).
The objective of this study is to investigate the mechanism by which GUTK sensitizes cancer cells to
cell death in nutrient starvation condition.
"Although free-floating viruses establish the initial infection, it is the subsequent cell-to-cell spread of HIV that causes massive CD4 T
cell death," says co-first author Nicole Galloway, PhD, a post-doctoral fellow at the Gladstone Institute of Virology and Immunology.
The two basic forms of
cell death, necrosis and apoptosis, play essential roles in development, homeostasis, and pathogenesis (1).
Professor Zhang found that a protein known as RIP1, previously linked to natural
cell death in the body, has a pro-survival function in melanoma cells.
Working with experts from Sweden, Germany and USA, they have discovered mechanisms that control a new form of premature
cell death in living tissue - called ferroptosis - and a way to reverse it.
He further added, "We found we can trigger
cell death with salt."
But if the problem doesn't resolve, the UPR triggers
cell death.
Cell survival and
cell death; a subject collection from Cold Spring Harbor perspectives in biology.